Computers and Electronics How profitable is owning a liquor store? How profitable is owning a liquor store? On average, liquor stores tend to have an overall profit margin of between 20% and 30% annually [4]. You can aim for a 50% profit margin if you choose (and are allowed to by your state).Jul 1, 2021 What is the largest liquor store? DaveCo Related Posts:Do smoothies have a high profit margin?How do I open a liquor store in Indiana?You can get a beer or liquor license in New York.You can get a New York beer or liquor license.