A consequence of its low reactivity is that PEG does not exhibit toxicity in humans also because mammals do not have enzymes which are able to metabolize PEG. Therefore, once ingested or parenterally administered PEG remains intact until it is eliminated via urine or feces.
Is PEG toxic to cells?
Most of the PEG oligomers are safe to both types of cells except triethylene glycol (TEG), which is toxic at high concentrations to L929 cells. Subsequently, those toxic PEG derivatives have been studied to reveal the different mechanisms of their toxicity.
What is polyethylene glycol PEG 6000?
Poly(ethylene glycol) 6000 is a high quality research product used as multipurpose polymer of ethelyne glycol for various biochemical, molecular biology and molecular diagnostic applications.
What is PEG additive?
Polyethylene glycol (PEG) is one of the additives used to promote pore formation in the polymeric membranes. PEG is a linear polyether compound available in a variety of molecular weight, which is indicated by a numeric suffix followed the abbreviation (PEG).Mar 1, 2011
Is PEG safe for humans?
Health and Environmental Hazards. Depending on manufacturing processes, PEGs may be contaminated with measurable amounts of ethylene oxide and 1,4-dioxane. The International Agency for Research on Cancer classifies ethylene oxide as a known human carcinogen and 1,4-dioxane as a possible human carcinogen.
What is the function of PEG?
PEG is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins. PEG is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.
What is PEG made of?
Polyethylene glycols (PEGs) are composed of polyether compounds repeating ethylene glycol units according to the constituent monomer or parent molecule (as ethylene glycol, ethylene oxide, or oxyethylene) (Fig. 1).
What does PEG mean in chemistry?
polyethylene glycol
What is the use of polyethylene glycol 6000?
What is it? Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments and suppository base, and tablet and capsule lubricant.
What is the difference between PEG 6000 and PEG 8000?
the number associated with the various pegs indicate the average molecular weight of the polymer. peg6000 and 8000 are the same, peg6000 was found to have an average fw of 8000 and was renamed. The clue is in the name - POLYethylene glycol!May 8, 2006
What is polyethylene glycol used for?
Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass.
What are the dangers of polyethylene glycol?
- irritation of the rectum.
- a sleep disorder.
- excessive thirst.
- nausea.
- vomiting.
- stomach cramps.
- abdominal bloating.
- a feeling of general discomfort called malaise.
Why is PEG used in drug delivery?
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune system and thereby prolong circulation lifetimes.