Neuron specific enolase (NSE) is a 78 kDa gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Measurement of NSE in serum or CSF can therefore assist in the differential diagnosis of a variety of neuron-destructive and neurodegenerative disorders.
What does high neuron specific enolase mean?
Cerebrospinal Fluid and Serum Markers Neuron specific enolase (NSE), an enzyme involved in glycolytic energy metabolism in the brain, is released from neurons during injury and is often elevated following GCSE. 218–220. NSE has therefore been proposed as a potential by a marker of neuronal injury in SE.
Where is neuron specific enolase found?
cytoplasm
What is a normal NSE level?
The median serum level of NSE was 18.4 ng/mL (3.4–344.2 ng/mL) for the entire population. Three-hundred and six (60.0%) patients had NSE more than or equal to 12.5 ng/mL, defined as high range.
What does neuron specific enolase indicate?
Neuron-specific enolase (NSE) is an acidic protease unique to neurons and neuroendocrine cells. It is a sensitive indicator for assessing the severity of nerve cell damage and prognosis1,2. It is also specific markers for tumors such as neuroblastoma and small cell lung cancer (SCLC)3,4.
What is a high NSE level?
In the context of a patient with a lung mass, disseminated malignancy of unknown origin or symptoms suggestive of paraneoplastic disease without identifiable tumor, elevated NSE suggests an underlying small cell lung carcinoma (SCLC).
What is NSE in medicine?
Neuron-specific enolase (NSE): Neuron-specific enolase (NSE) is a substance that has been detected in patients with certain tumors, namely: neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma.
What is neuron specific enolase CSF?
Neuron-specific enolase (NSE) is a neuronal glycolytic enzyme of which cerebrospinal fluid (CSF) levels are found altered following acute or prolonged neuronal damage. Investigations concerning the role of NSE in Alzheimer's disease (AD) are conflicting with both elevated and reduced levels.Jun 6, 2014
What is NSE neurology?
Background: Neuron-specific enolaseNeuron-specific enolaseBackground: Neuron-specific enolase (NSE) is a well known marker of small cell lung cancer. The present study was designed to assess the clinical value of NSE in non-small cell lung cancer (NSCLC), as compared to that of carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA).https://pubmed.ncbi.nlm.nih.gov › Neuron-specific enolase is an effective tumour marker in non (NSE) is a widely-used biomarker for prognostication of neurological outcome after cardiac arrest, but the relevance of recommended cutoff values has been questioned due to the lack of a standardized methodology and uncertainties over the influence of temperature managementtemperature managementInduction of hypothermia is the process in which a target core temperature of 32 to 34 degrees Celsius is reached as quickly as possible. This is achievable through several different external and internal cooling mechanisms.https://www.ncbi.nlm.nih.gov › books › NBK556124Targeted Hypothermia Temperature Management - StatPearls - NCBI.
What is NSE blood test?
Description. The Neuron-specific Enolase Blood Test, or NSE Blood Test, is useful in the diagnosis and ongoing monitoring of patients with small cell lung carcinoma (SCLC). It may also be used in the diagnosis of other neuroendocrine tumors such as carcinoids, islet cell tumors and neuroblastomas.
What is the normal range of NSE?
Twenty eight healthy adults had NSE serum level ranging from 2.58 to 17.41 ng/ml (mean level 8.01 +/- 4.40 ng /ml). The upper limit of the normal interval for serum NSE 16.6 ng/ml is defined as the mean value for healthy con- trols plus 1.96 standard deviations.