Nav1. 7 is expressed on the surface of peripheral pain-sensing neurons, or nociceptors, where it conducts Na+ currents in response to membrane depolarizations that are generated by potentially tissue-damaging events, triggering action potential firing and sending pain signals.Apr 8, 2019
Is Nav1 7 a protein?
Nav1. 7, known to regulate opioid receptor efficacy, interacts with the G protein-regulated inducer of neurite outgrowth (Gprin1), an opioid receptor-binding protein, demonstrating a physical and functional link between Nav1.Feb 1, 2018
What does the SCN9A gene do?
Normal Function The SCN9A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged sodium atoms (sodium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals.
How do sodium ion channels work?
Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. Sodium channels have a modular architecture, with distinct regions for the pore and the gates.
What is the Nav 1.7 channel?
Nav1.7 is a sodium ion channelsodium ion channelSodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.https://en.wikipedia.org › wiki › Sodium_channelSodium channel - Wikipedia that in humans is encoded by the SCN9A gene. It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at dorsal root ganglion (DRG) and trigeminal ganglion and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.
Where are sodium channels located?
There are two major classes of sodium channels in mammals: The voltage-gated sodium channel (VGSC) family and the epithelial sodium channel (ESC). Voltage-gated sodium channels exist throughout the body in various cell types, while epithelial sodium channels are located primarily in the skin and kidney.