Exercise. Other research on mice suggests that a protein called irisin may help transform white fat to brown. Humans also produce this protein. Researchers uncovered that people who are sedentary produce far less irisin compared to those who exercise often.
What supplement turns white fat into brown?
White fat can be “browned” with a class of drugs called thiazolidazines (TZDs), which increase the body's sensitivity to insulin. However, TZDs have many adverse effects—including liver toxicity, bone loss, and, ironically, weight gain—which have limited the use of these drugs.
Can white adipose tissue turn into brown?
PATHWAYS TO INDUCE BROWNING The most studied pathway known to induce the browning of white adipocytes works through the actions of norepinephrine. This is released from sympathetic nerve endings and acts on β-adrenergic receptors on the surface of adipocytes.
How does brown adipose tissue develop?
Brown adipocytes are thought to originate from the mesoderm during embryonic development and thus share a very early developmental origin with skeletal muscle, bone, white adipocytes, and connective tissues (Wang et al., 2014b, Atit et al., 2006, Seale et al., 2008, Lepper and Fan, 2010, Sanchez-Gurmaches et al., 2012) ...2 jul 2020
What is adipose tissue browning?
A hallmark feature of adipose tissue browning is the induction of thermogenically active adipocytes in white fat depots. These adipocytes are often referred to as beige or brite (brown in white) cells and express high amounts of the key thermogenic factor uncoupling protein 1 (UCP1).1 jun 2019
How do you activate brown fat?
Brown adipose tissue activation occurs most effectively by cold exposure. In the modern world, we do not spend long periods in cold environment, and eating and meals may be other activators of brown fat function. Short-term regulation of brown fat functional activity by eating involves most importantly insulin.