The Depyrogenation oven for depyrogenation and dry heat sterilization provides complete destruction of micro-organisms by means of a controlled temperature for a controlled period of time. The sterilizing effect is calculated by the PLC (F-calculation).
What is Depyrogenation by dry heat?
Dry heat sterilization (or Depyrogenation) is a process aimed at the reduction in the level of pyrogens with the use of hot air in temperature ranging from 160°C up to 400°C. The temperature used depends on the duration of the process. ... Depyrogenation is mainly used in the sterilization of vials for aseptic filling.
What is Depyrogenation tunnel?
Depyrogenation tunnels are used in pharmaceutical filling lines to sterilize glass containers before they are aseptically filled. These tunnels use unidirectional hot air at temperatures up to 600° F (350° C) and can be used to sterilize and depyrogenate glass vials, ampoules, and cartridges.
Does Depyrogenation sterilize?
Depyrogenation of glass vial is very popular for sterilizing pharmaceutical vials. It involves heating articles in depyrogenation tunnel which have been specifically designed for the process for thermal stable articles where the normal sterilization process has failed to eliminate them.
How does a depyrogenation oven work?
Lytzen depyrogenation ovens operate in accord- ance with the forced convection principle with fast heat transmissionheat transmissionHeat flux or thermal flux, sometimes also referred to as heat flux density, heat-flow density or heat flow rate intensity is a flow of energy per unit of area per unit of time. In SI its units are watts per square metre (W/m2). ... , the subscript q specifying heat flux, as opposed to mass or momentum flux.https://en.wikipedia.org › wiki › Heat_fluxHeat flux - Wikipedia to the load. Together with the shape and position of the heat- ing element and the computer designed air distri- bution plate, a unique temperature distribution inside the chamber is ensured.
What is depyrogenation temperature?
Dry heat sterilizationDry heat sterilizationThe proper time and temperature for dry heat sterilization is 160 °C (320 °F) for 2 hours or 170 °C (340 °F) for 1 hour or in the case of High Velocity Hot Air sterilisers 190°C (375°F) for 6 to 12 minutes. Items should be dry before sterilization since water will interfere with the process.https://en.wikipedia.org › wiki › Dry_heat_sterilizationDry heat sterilization - Wikipedia (or Depyrogenation) is a process aimed at the reduction in the level of pyrogens with the use of hot air in temperature ranging from 160°C up to 400°C. The temperature used depends on the duration of the process.
How does a depyrogenation tunnel work?
Depyrogenation tunnels are used in pharmaceutical filling lines to sterilize glass containers before they are aseptically filled. These tunnels use unidirectional hot air at temperatures up to 600° F (350° C) and can be used to sterilize and depyrogenate glass vials, ampoules, and cartridges.
Does depyrogenation sterilize?
Depyrogenation of glass vial is very popular for sterilizing pharmaceutical vials. It involves heating articles in depyrogenation tunnel which have been specifically designed for the process for thermal stable articles where the normal sterilization process has failed to eliminate them.
What is depyrogenation by dry heat?
Dry heat sterilization (or Depyrogenation) is a process aimed at the reduction in the level of pyrogens with the use of hot air in temperature ranging from 160°C up to 400°C. The temperature used depends on the duration of the process. ... Depyrogenation is mainly used in the sterilization of vials for aseptic filling.
What is the meaning of depyrogenation?
Depyrogenation refers to the removal of pyrogens from solution, most commonly from injectable pharmaceuticals. A pyrogen is defined as any substance that can cause a fever. Bacterial pyrogens include endotoxins and exotoxins, although many pyrogens are endogenous to the host.