FFR value represents the fraction of the normal maximal myocardial flow that can be achieved despite the coronary stenosis. For example, an FFR of 0.75 means that the stenotic vessel only provides 75% of the normal expected flow in the theoretical absence of the stenosis.
Why is FFR important?
FFR is a valuable tool to determine the functional significance of coronary stenosis. It combines physiological and anatomical information, and can be followed immediately by percutaneous coronary intervention (PCI) if necessary.
When is FFR?
Fractional flow reserve (FFR) is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, usually due to atherosclerosis) to determine the likelihood that the stenosis impedes oxygen delivery to the heart muscle (myocardial ischemia).
What does FFR negative mean?
For the most part, a negative FFR predicts the ability to safely defer interventional treatment of an intermediate lesion, with a relatively low risk of downstream events.1 Dec 2014
What is an abnormal FFR?
There is no absolute cut-off point at which FFR becomes abnormal; rather, there is a smooth transition, with a large grey zone of insecurity. In clinical trials however, a cut-off point of 0.75 to 0.80 has been used; higher values indicate a non-significant stenosis, whereas lower values indicate a significant lesion.
What is the cutoff for FFR?
In per-vessel analysis, the conventional cutoff value of FFR ≤0.80 was associated with low specificity and high false-positive rate with invasive FFR ≤0.80 as the reference standard for hemodynamically significant ischemia.1 Aug 2019
What is significant iFR?
iFR® cut-off value and fractional flow reserve-measurement: An iFR®-value of ≤ 0.89 indicates a hemodynamically significant stenosis (above, red bars), whereas an iFR®-value of ≥ 0.90 indicates no need for an intervention (green bar).26 Dec 2018
What is FFR procedure?
Fractional Flow Reserve (FFR) is a procedure used to measure blood pressure and flow through a specific part of a coronary artery. We perform it at the time of a coronary angiogram, to assess whether or not to perform angioplasty and stenting on mid-size blockages.
What is significant FFR?
2. FFR is defined as the ratio of mean distal coronary pressure to mean aortic pressure. Incorporating stenosis severity, myocardial territory and viability, and collateral perfusion, FFR is able to fully assess the functional significance of a coronary stenosis.25 May 2017
Who invented FFR?
Since then, clinical application of intracoronary pressure had been almost forgotten until the concept of myocardial FFR was developed and introduced by N. Pijls and B. De Bruyne in the early 1990s. The concept was first validated in an animal study12) and later in humans using a positron emission tomography scan.26 Jul 2012
How is FFR test done?
FFR uses a small sensor on the tip of the wire (commonly a transducer) to measure pressure, temperature and flow to determine the exact severity of the lesion. This is done during maximal blood flow (hyperemia), which can be induced by injecting products such as adenosine or papaverine.
What is FFR test?
Fractional Flow Reserve Computed Tomography (FFR-CT) is a noninvasive technology developed by HeartFlow Inc. to test for coronary artery disease. HeartFlow® technology uses computed tomography (CT) scans to calculate how much blood is flowing through the coronary arteries.