The cell line in this case is called WI-38, in which the initials represent the Wistar Institute of Anatomy and Biology in Philadelphia, Pennsylvania, where the early work was done.26 jun 2013
What is WI-38 used for?
WI-38 was fundamental for the development of vaccines against polio, measles, mumps, rubella, varicella zoster (chicken pox), herpes zoster, adenovirus, rabies and Hepatitis A, as well as in the production of many early vaccines.4 nov 2020
Is WI-38 immortalized?
Immortalization of human WI38 cells is associated with differential activation of the c-myc origins. J Cell Biochem.
What is WI-38 in vaccines?
Virus vaccines produced in WI-38 have prevented disease or saved the lives of billions of people. Vaccines produced in WI-38 include those made against adenoviruses, rubella, measles, mumps, varicella zoster, poliovirus, hepatitis A and rabies.
Where do cell lines come from?
Introduction. Cell lines are cultures of animal cells that can be propagated repeatedly and sometimes indefinitely. They arise from primary cell cultures. Primary cultures are initiated directly from the cells, tissues, or organs of animals and are typically used in experiments within a few days.
Where does WI-38 come from?
WI-38 is a diploid human cell line composed of fibroblasts derived from lung tissue of a 3-month-gestation female fetus. The fetus came from the elective abortion of a Swedish woman in 1962, and was used without her knowledge or permission.
What vaccines is WI-38 used in?
Vaccines for the following virus-based diseases were developed using WI-38: poliomyelitis, measles, mumps, rubella, varicella (chicken pox), herpes zoster,6 adenovirus, rabies and Hepatitis A.2 mar 2017