Arts and Entertainment Will baking soda clog a drain? Will baking soda clog a drain? Even newly installed plumbing can pose problems out of the blue. In reality, even simple DIY methods like the baking soda and vinegar technique that's often used to clear a drain clog, can be harmful to your plumbing system. Related Posts:What does baking soda do to your body?What can dissolve hair in a drain?What is the best homemade drain cleaner?How to remove yellow stains from toilet bowl and seat